Combining poppers (alkyl nitrites) with Cialis (tadalafil) is extremely dangerous and should be avoided. Both substances significantly lower blood pressure. When taken together, they can cause a sudden and severe drop in blood pressure, leading to dizziness, fainting, heart attack, or even death.

Poppers are often used recreationally for muscle relaxation and euphoria, but mixing them with a PDE5 inhibitor like Cialis puts serious strain on the cardiovascular system. Always consult a healthcare provider before mixing any medications or substances.

Bottom line: Never use poppers while taking Cialis. Your heart—and your health—depend on it.